ANTIDIABETIC PROPERTY OF METHANOL EXTRACT OF B. ALBA (FRUITS ALONG WITH SHOOTS) AND ITS RELATIONSHIP WITH THE ANTIOXIDANT PROPERTY

A.K.Azad, Kushal Biswas, Ohidul Islam, Md. Saifuddin, Manirul Islam, M. Khairuzzaman, Nandita Das, Nazneen Ahmeda Sultana, Sophia Hossain, Sanjida Haque, Nilima Karmoker, Anwarul Islam

International Journal of Pharmaceutical Research and Innovation, Vol. 9, 2016, 9-16

Download

Email

Description

ABSTRACT

Diabetes is one of the most life threatening diseases of the present world. Among many causes excessive oxidative reactions are notable of them. The present study was designed to evaluate the comparative studies on antidiabetic and antioxidant properties of B. alba. Antidiabetic study was carried out on experimental animal model (Swiss albino mice) for 120 minutes treatment and significant blood sugar decline was observed (16.94 to 7.94mM/L) at the dose of 250mg B. alba extract and (20.0 to 7.30 mM/L) at 500mg dose compared to control group whereas metformin was taken as a reference standard. Antioxidant property was done through free radical scavenging method. Methanol extract of B. alba showed IC50 496.32 (µg/ml). Where, Ascorbic acid was used as a standard with IC50 of 4.78 (µg/ml).

Key words: Antidiabetic, Alloxan, Metformin, antioxidant, DPPH, free radical, B. alba