COMPARATIVE STUDIES ON ANTIOXIDANT AND THROMBOLYTIC ACTIVITIES OF METHANOL AND ETHYLACETATE EXTRACTS OF TREMA ORIENTALIS

International Journal of Innovations in Biological and Chemical Sciences, Volume 9, 2016, 47-51

A.K.Azad, Shoumen Lasker, Irfan-Ur-Rahaman, Ohidul Islam, Sharmin Akter M.

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ABSTRACT

The present study was carried out to evaluate in-vitro antioxidant, and thrombolytic activity of MeOH and EtOAc extracts Trema orientalis flowers. Antioxidant activity of the extracts was tested by using DPPH (1, 1-diphenyl-2-picrylhydrazyl) free radical scavenging assay method whereas the thrombolytic activity was tested by in-vitro clot lysis assay method. The MeOH extract of T. orientalis showed mild free radical scavenging activity (IC50: 131.2µg/ml) compared to ascorbic acid (IC50:12.4µg/ml) used as a standard. On the other hand, both MeOH and EtOAc extract produced 21.4 and 21.5% clot lysis respectively compared to streptokinase used as a positive control that caused 51% clot lysis.

Keyword: DPPH, streptokinase, antioxidant activity, thrombolytic activity, Trema orientalis