COMPUTATIONAL PREDICTION OF POTENTIAL GENES: INVOLVE IN DIFFERENT HUMAN DISEASES FIND OUT WITH THE HELP OF C. ELEGANCE NUCLEOTIDES

European Journal of Bioinformatics Volume 4, 2016, 13-16

Shashi Prabha Agrawal, Alka Dubey, Neelesh Yadav, Rajnish Kumar

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ABSTRACT

  Micro RNAs of C.elegans are small, non-coding regulatory RNAs. The C. elegans genome encodes hundreds of miRNAs. Computational prediction and systematic cloning of miRNA reveals that hundreds of genes encoding miRNAs exist in the genome of C.elegance. In the present study, we describe a computational procedure to identify miRNA genes conserved in more than one genome. Applying this program, known as DINA, together with molecular identification and validation methods. Many of these miRNA conserved in other organism.  We identified 610 genes from C. elegance miRNAs and these identified genes play a very important role in human genomic functions.

Keywords:miRNA,  C. elegans , Genomic function.