HYPERBILIRUBINEMIA IN PATIENTS WITH LONG BONE FRACTURES

International Journal of Innovations in Biological and Chemical Sciences, Vol. 6, 2015, 45-47

Gomathy R, Suman Doddamani, Lakshmi K.S, Arundathi S, Prathibha S, Veni

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ABSTRACT

BACKGROUND: Hyperbilirubinemia is defined as excess of bilirubin in the blood, occurring as a result of liver or biliary tract dysfunction or with excessive destruction of red blood cells.

AIMS AND OBJECTIVES: To evaluate the levels of serum bilirubin in patients with long bone fractures.

MATERIALS AND METHODS: 200 participants were enrolled in the study. 100 patients with long bone fracture were taken as study group and 100 age and sex matched healthy participants were taken as control group. The serum samples of the patients were used for measuring various parameters. Total and direct bilirubin were measured by Photometric test using 2, 4 dichloroaniline. Alkaline phosphatase, Alanine transaminase and Aspartate transaminase enzyme levels were measured by Optimized UV test according to International Federation of clinical chemistry and Laboratory medicine.

RESULTS: We found an increase in levels of Bilirubin, SGOT and SGPT in patients with long bone fractures compared to the control group.

CONCLUSION:  The study concluded that patients with long bone fractures developed hyperbilirubinemia and hepatic dysfunction. Hence it is important to evaluate bilirubin levels early so that patients with long bone fractures can be prevented from developing sepsis or other liver complications.              

KEY WORDS: Bilirubin, Fractures, Hyperbilirubinemia, Liver dysfunction