In the present investigation, osmotic pump capsule were designed, for delivery of poorly water-soluble drug flurbiprofen. The capsule membrane was prepared by phase inversion technique involving dipping of stainless steel moulds in the solution of cellulose acetate containing castor oil as plasticizer. The drug selected for this study, flurbiprofen, has low aqueous solubility and hence would be unable to create enough osmotic pressure to cause its own release. This study was conducted with a solubility enhancer, sodium lauryl sulfate to enhance solubility of the drug and the osmotic pressure of the core. The release of flurbiprofen from the developed osmotic pump was inversely proportional to the osmotic pressure of the release medium, suggesting that the osmotic release was the major mechanism for the release of the drug. Key words: capsule, cellulose acetate, castor oil, flurbiprofen, osmotic release.
Keywords; capsule, cellulose acetate, castor oil, flurbiprofen, osmotic release.