The Role Of Acid-Hydrolysed Cassava Starch As A Binder In Paracetamol Tablets

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International Journal of Pharmaceutical Research and Innovation, Vol. 4: 6-9, 2011

THE ROLE OF ACID-HYDROLYSED CASSAVA STARCH AS A BINDER IN PARACETAMOL TABLETS
Mohammed B.B, Isah A.B, Apeji Y.E

Department of Pharmaceutics and Pharmaceutical Microbiology Ahmadu Bello University, Zaria, Nigeria.

Department of Pharmaceutics and Pharmaceutical Microbiology Ahmadu Bello University, Zaria, Nigeria.

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Abstract
Modified cassava starch has been evaluated as a binder in paracetamol tablet formulations. The starch was extracted from the fresh tubers of manihot esculenta, modified by heat and acid treatments for 24 hours. The binding property of the modified starch was investigated in paracetamol tablets formulated by wet granulation using polyvinlpyrrolidone (PVP) and maize starch BP as basis for comparison at concentrations of 2.5 – 10% w/v. The tablets were evaluated for hardness, friability, weight uniformity, disintegration and dissolution profiles. Results obtained indicated that modified starch performed as good as PVP and maize starch BP as a binder in paracetamol tablet formulations especially at a concentration of 10%w/v.

Keywords: Modified starch, Paracetamol, PVP, Maize starch, Binder