International Journal of Pharmaceutical Research and Innovation, Vol. 4: 32-39, 2011
THE ROLE OF ACID TREATED SWEET POTATO STARCH (MICROCRYSTALLINE STARCH) ON DISINTEGRANT PROPERTY OF PARACETAMOL TABLET FORMULATION.
S. J. Madu , J. Muazu and G. T. Mohammed
Department of Pharmaceutics and Pharmaceutical Microbiology, University of Maiduguri, Nigeria.
Acid treated sweet potato (Ipomea batatas) starch (microcrystalline starch) was evaluated as a disintegrant using paracetamol tablet formulation and compared with similar concentrations of untreated sweet potato starch and maize starch B.P. Concentrations of 2.5, 5, 7.5 and 10%w/w disintegrant were incorporated as intradisintegrants in the study. The sample starch powders used were characterized and the various properties of the starch powders compared. Wet granulation method was adopted for the production granules. The compacts formed (tablets) were subsequently subjected to quality control tests; uniformity of thickness and diameter, uniformity of weight test, crushing strength, friability test, disintegration and dissolution rate tests. The results obtained indicated that acid treated sweet potato starch has a better disintegrant property compared to untreated sweet potato and maize starch B.P. By implication, acid treated sweet potato starch can therefore be used as an alternative disintegrant to maize starch B.P.
Keywords: Acid Treated Sweet Potato Starch, Disintegrant, Starch, Paracetamol, Tablet