Context: Herpes genitalis is a common sexually transmitted disease caused by herpes simplex virus. Effective treatment is available for the active disease, but no modality has been found to curtail its recurrent nature. Aims: Comparative evaluation of therapeutic efficacy of topical silver nitrate (AgNO3) in combination with oral zinc sulfate in recurrent herpes genitalis. Methods and Material: A total of 60 patients clinically diagnosed as recurrent herpes genitalis (with 2 or more episodes in last 6 months) with a positive Tzanck smear were divided into 2 groups (test and control) of 30 patients each. Patients in test group were treated with topical application of 10% AgNO3, and then repeated every week, till lesions cleared, or for a maximum of 4 applications along with oral zinc sulfate. In control group distilled water was applied. Patients were followed up for a total period of 24 weeks Results were analysed statistically. Results: In test group only 9 (30%) out of 30 patients showed recurrence, whereas in control group 21 (70%) out of 30 patients showed recurrence. Conclusion: Topical AgNO3 in combination with oral zinc sulfate has been found to be an effective therapeutic modality not only for treatment but also for preventing recurrence of herpes genitalis and prolonging remissions.
KEY WORDS: Herpes genitalis, recurrent, silver nitrate, zinc sulfate