The antidiabetic potentials of yoyo bitters compared with known antidiabetic drug, glilbenclamide were studied in Aloxan induced diabetic rats for the period of 28 days. Yoyo bitters at high dose of 23.24 ml/kg-1 effected a significant reduction (P< 0.01) in blood glucose level as compared to the controls, without glibenclamede and glibenclamide treatment on days 14 21 and 28 days. However, there was a significant (P < 0.001) fasting blood glucose level on day 7 as compared to glibenclamide treated group. At the median dose of 15.49ml/kg-1 yoyo bitters produced a significant (P < 0.001) reduction in glucose level at 7, 14, 21 and 28 days as compared to glibenclamide treated group. Yoyo bitters at the low dose of 7.75ml/kg-1 also produced a significant (P < 0.001) reduction in fasting blood glucose levels on days 7, 14, 21 and 28 days compared to glibenclamide group. At the 28th day of low dose treatment, yoyo bitters restored the fasting blood glucose level as compared with control, glibenclamide. The blood glucose levels’ with yoyo bitters were dose and periodic dependent. The study observed a high antidiabetic potentials of yoyo bitters as that of glibenclamide and could be used as alternative drug in the treatment of diabetes.
Key words: Yoyo bitters, glibenclamide, diabetes.