Description

ABSTRACT

Introduction: Analytical chemistry is the study of the chemical composition of natural and artificial materials. Unlike other major sub-disciplines of chemistry such as inorganic chemistry and organic chemistry, analytical chemistry is not restricted to any particular type of chemical compound or reaction.
Aim and Objectives: To develop and validate the analytical methods for estimation of etodolac in bulk and pharmaceutical dosage form using U.V spectroscopy. To study solubility characteristics of etodolac. To determine absorbance maxima for etodolac. To develop selective, precise and sensitive methods for the development and estimation of etodolac in bulk and pharmaceutical dosage form.
Results and Conclusion: Improvement and validation of two visible spectrophotometric methods applying methanol and water as reagents for etodolac determination in investigated formulations were successfully carried out. The near 100 % recoveries and low relative standard deviation values obtained, point to the suitability of both modified and validated methods for the determination of etodolac in human and veterinary medicine. It was concluded that the UV spectroscopic method could be used for the simultaneous determination of trimethoprim immediate-release oral dosage forms. This method could be used for the analysis of active pharmaceutical ingredients in dissolution studies and for quality control purposes. The method is rapid, simple, and economic without the need of high-cost investment.

Keywords: Simultaneous, Determination Development, Estimation, Spectroscopy