Description

ABSTRACT

The present study was undertaken to investigate the effects of methanol and aqueous extracts of Alangium salvifolium Linn. seeds in anxiety on rats by using elevated plus maze and light & dark models. Evaluating the motor coordination activity of Alangium salvifolium seeds extracts using actophotometer models. Wistar rats (either sex) were treated orally with methanol and aqueous extracts of Alangium salvifolium seeds (200mg/kg, 400mg/kg, 800mg/kg, 1200mg/kg, 1600mg/kg) and diazepam (2mg/kg) as a standard anxiolytic drug. The results showed that the extracts of methanol and aqueous significantly induced maximum increase in the both number of entries and time spent in open arms, compared to the closed arm in an elevated plus-maze model. In the light-dark exploration test model, results showed that the extracts of methanol and aqueous significantly induced maximum increase in the time spent in the light compartment, compared to the dark compartment. In the actophotometer model, results showed that the methanol and aqueous extracts significantly increased motor coordination activity. Despite these two extracts, methanol extract was found to be most effective (at dose 1200mg/kg). These results compared with the control group and diazepam (2mg/kg), treated group.

Keywords: Elevated Plus Maze (EPM), Gaba Amino Butyric Acid (GABA), Noradrenaline (NA), Selective Serotonin Reuptake Inhibitors