Description

ABSTRACT

Introduction: Diabetes is a metabolic disorder characterized by hyperglycaemia& raised HbA1c. Serum Ferritin is an acute phase protein and it is a marker of iron stores in the body. Excess iron damages β-cells of pancreas due to oxidative stress contributing to pathogenesis of diabetes mellitus. The complications of diabetes mellitus are influenced not only by the duration of the diabetes mellitus but also by the average level of blood glucose along with glycated haemoglobin. Raised serum ferritin may possibly be related to the occurrence of long term complications of diabetes, both micro vascular and macrovascular. Objective: The aim of this study is to establish an association of Serum Ferritin with Type-2 Diabetes Mellitus-A Case Control Study in Rajshahi Medical College Hospital, Rajshahi, Bangladesh. Materials and Methods: This study was done in the Department of Medicine, Rajshahi Medical College, Rajshahi, Bangladesh done from July-2018 to Jun-2019. The study comprised of total 100 subjects. Blood samples were analysed for Ferritin, HBA1C and fasting plasma glucose. Results: Serum ferritin was significantly higher in diabetic patients when compared with control group (p<0.001). Serum ferritin is positively correlated with HbA1c and also serum ferritin had a positive correlation with increasing duration of diabetes. Conclusion: Serum ferritin and HBA1C level were elevated in patients with type 2 diabetes mellitus when compared to healthy individuals and it indicates that serum ferritin can be used as a marker for glycemic control in diabetic patients.

Keywords: Diabetes Mellitus, HBA1C, Ferritin