Description

SPECIAL ISSUE: COVID-19: A HOLISTIC INSIGHT

ABSTRACT

Wuhan, Hubei province, China became an epicentre of an outbreak pandemic SARS-CoV-2 in December 2019. As per World Health Organization (WHO) China expressed its first case of SARS-CoV2 sequence on 12 January 2020 and the first case of SARS-CoV-2 have been reported outside China was on the 13 January 2020 at Thailand. Form the day one to till today there are no outcome of effective drugs against SARS-CoV-2 pandemic. As of 8:40 PM IST, 11 May 2020, the global count of confirmed COVID-19 cases has reached 41,32,365, with as many as 2,83,387 victims succumbing to the same. The SARS-CoV-2 virus shows a high sequence similarity, of about 70-80%, to the SARS-CoV viruses. Additionally, either of them shows an identical clinical symptom such as respiratory illness, fever, dry cough, and with complications like chest pain or pressure, loss of speech and movement. The current review focuses on potential drugs against the SARS-CoV-2 virus, with an emphasis on the major drug interactions, functions and features of the Human Corona 229E strain.

 Keywords: Chloroquine, Human Coronavirus, Human Corona229E, Potential drugs, Remdesivir, SARS-CoV-2