Description

ABSTRACT

Laron syndrome (LS) or primary growth hormone insensitivity is a genetic disorder known for a type of dwarfism characterized by short stature, facial phenotype, obesity and unexpected high serum GH levels. The disorder is caused due to the mutation of Growth Hormone receptor (GHR) gene whose inability to synthesize IGF-I and other related molecules leads to insulin-like growth factor-1 (IGF-1) deficiency and was first described by Zvi Laron et al., in 1966 as a new type of dwarfism and has garnered interest among genetics and medical fraternities where the LS patients are known to have a lower cancer risk. The review presents the baseline clinical and genetic aspects of the condition along with a broader overview of hypothesized disease presentations of possible protective mechanisms against cancer induction.

 Keywords: Laron syndrome, Growth hormone receptor, Insulin-like growth factor-1, Dwarfism, Cancer protection