Description

ABSTRACT

The Latin word ‘inflammation’ means to set on fire. Vasodilation which increases blood flow is one of main events which results the skin redness, and other event is swelling because of interstitial fluid increases as capillaries and venules become leakier.Anti-inflammatory drugs are used to cure inflammation. The pharmacological activity of NSAIDs is due to suppression of prostaglandin biosynthesis from arachidonic acid by inhibiting the enzyme cyclooxygenases (COXs) which exists in two isoforms, COX-1 and COX-2, which were regulated differently. 1,3,4-oxadiazoles represent a class of heterocyclic compounds of great importance in biological chemistry.

Keywords: Inflammation, Vasodilation, Defensive mechanism, Pharmacological screening