Description

ABSTRACT

The authors studied the fate of different living bacteria given orally to mice or adult volunteers in the years of late 60th and early 70th. Furthermore, consequences of consuming of heat killed bacteria and lyophilized Boivin’s extract/endotoxin prepared from different intestinal bacteria and Salmonella cells excreted by patients suffering from food-borne infection were also examined. It was observed that neither the consumption of high dose Boivin’s extract nor a great amount of heat killed bacteria caused any visible enteric or general symptoms in men. When great amount of non-pathogenic living bacteria were administered orally to mice or such bacteria were engulfed by the volunteers the germs disappeared from their faces after some days seemingly without eliciting any symptoms. But when non-virulent Salmonella bacteria were used in case of mice a long excretion was observed. If infant specific Escherichia coli bacteria were consumed by adult volunteers then diarrhoe and cramps appeared in some cases. On the basis of the data it can be stated that the non-pathogenic bacteria administered by oral route disappear from the bowel of mice and men after some days but the pathogenic ones are present in the faecal samples for longer time in accordance with their invasive and multiplying capacity.

Keywords: Administration, bacteria, endotoxin, mice, volunteers, excretion